Description

1-(Trifluoromethanesulfonyl)Imidazole is a versatile and highly reactive trifluoromethanesulfonyl (triflyl) transfer reagent. This compound is valued for its ability to efficiently introduce the electron-withdrawing triflyl group, making it a critical intermediate in advanced organic synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules and developing novel synthetic methodologies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring sulfonamide or triflyl-protected functional groups.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethanesulfonyl moiety enhances biological activity and stability.
• Peptide Chemistry: Acts as a coupling agent or protecting group reagent in the synthesis of peptides and peptidomimetics.
• Material Science: Intermediate in the creation of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Cross-Coupling Reactions: Serves as a precursor to generate reactive intermediates like triflyl azides or other reagents used in metal-catalyzed cross-coupling processes.
• Research & Development: Essential reagent in academic and industrial R&D labs for methodological studies in organic synthesis and new reaction development.

Basic Information

Product Name	1-(Trifluoromethanesulfonyl)Imidazole
CAS No.	29540-81-6
Molecular Formula	C4H3F3N2O2S
Molecular Weight	200.14 g/mol
Synonyms	1H-Imidazole, 1-[(trifluoromethyl)sulfonyl]-; Trifluoromethanesulfonyl Imidazole; Imidazole, 1-(trifluoromethanesulfonyl)-; 1-(Triflyl)imidazole; N-Triflylimidazole; Tf-Imidazole; N-[(Trifluoromethyl)sulfonyl]imidazole; 1-(Trifluoromethanesulfonyl)-1H-imidazole
EINECS	Contact for details

Quality Control

Our 1-(Trifluoromethanesulfonyl)Imidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring reliable and reproducible performance in sensitive synthetic processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.