Description

Z-Arg(Tos)-Oh Cha is a protected arginine derivative, specifically the tosyl (Tos) protected form of Z-Arg-OH. This compound is a critical building block in peptide synthesis, valued for its role in introducing the arginine amino acid residue while protecting its reactive guanidino side chain. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the development of novel peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, stepwise construction of complex peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for producing custom peptides and peptide fragments.
• Pharmaceutical Intermediate: Serves as a crucial raw material in the research and production of peptide drugs targeting various diseases.
• Bioconjugation: Acts as a linker or spacer molecule in the creation of peptide-protein or peptide-small molecule conjugates.
• Biochemical Research: Employed in studying enzyme-substrate interactions, protein folding, and signal transduction pathways involving arginine.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of peptide linkers that connect cytotoxic drugs to monoclonal antibodies.

Basic Information

Product Name	Z-Arg(Tos)-Oh Cha
CAS No.	29388-62-3
Molecular Formula	C₂₁H₂₆N₄O₆S
Molecular Weight	462.52 g/mol
Synonyms	Nα-Carbobenzoxy-Nω-tosyl-L-arginine; Z-Arg(Tos)-OH; Z-Nω-Tosyl-L-arginine; Nα-Benzyloxycarbonyl-Nω-(p-toluenesulfonyl)-L-arginine; Benzyl N-[4-[[(4-methylphenyl)sulfonyl]amino]-1-(carboxymethyl)butyl]carbamate; L-Arginine, N2-[(phenylmethoxy)carbonyl]-N5-[(4-methylphenyl)sulfonyl]-; CBZ-Arg(Tos)-OH
EINECS	Contact for details

Quality Control

Our Z-Arg(Tos)-Oh Cha is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with every shipment, detailing all critical specifications to ensure the material meets the stringent requirements for pharmaceutical research and cGMP-guided production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	-10.0° to -12.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.