Description

Boc-Asp(Otbu)-Onp is a high-purity, protected amino acid derivative widely used as a critical building block in peptide synthesis. This compound matters because it offers exceptional selectivity and stability during complex coupling reactions, enabling the efficient production of sophisticated peptides. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic peptides, APIs, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key activated ester intermediate for the controlled incorporation of aspartic acid into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical solution methods for synthesizing specific peptide fragments and conjugates.
• Pharmaceutical Intermediate: Serves as a crucial raw material in the synthesis of peptide-based Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Biochemical Research: Employed in academic and industrial R&D for studying protein structure-function relationships and enzyme mechanisms.
• Production of Protected Peptide Fragments: Enables the synthesis of complex, side-chain protected peptide segments for convergent synthesis strategies.
• Labeled Peptide Synthesis: Useful for introducing aspartic acid residues when synthesizing isotopically or fluorescently labeled peptides for diagnostic and research applications.

Basic Information

Product Name	Boc-Asp(Otbu)-Onp
CAS No.	29365-05-7
Molecular Formula	C19H26N2O7
Molecular Weight	394.42 g/mol
Synonyms	Boc-L-Aspartic acid 4-benzyl ester N-hydroxysuccinimide ester; N-(tert-Butoxycarbonyl)-L-aspartic acid β-benzyl ester N-succinimidyl ester; Boc-Asp(OBzl)-OSu; Boc-Asp-OBzl-OSu; Nα-Boc-Nβ-benzyl-L-aspartate N-succinimidyl ester; (2S)-4-Benzyl 1-[(2,5-dioxopyrrolidin-1-yl)oxy]-3-[(2-methylpropan-2-yl)oxycarbonylamino]-1,4-dioxobutan-2-yl] benzenecarboxylate; Boc-Aspartic acid β-benzyl ester N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Boc-Asp(Otbu)-Onp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure compliance with exacting research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Melting Point	105°C - 110°C
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.