Description

Glycyl-Glycyl-Tyrosyl(o-Benzyl)-Arginine is a synthetic, protected tetrapeptide sequence of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled construction of larger, biologically active peptides and proteins. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic agents, enzyme substrates, or diagnostic tools. The o-Benzyl protection on the tyrosine residue provides essential stability during synthetic procedures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a standard or substrate in enzymatic studies, particularly for protease and kinase activity assays.
• Peptide Library Construction: An essential building block for combinatorial chemistry and the generation of diverse peptide libraries for drug discovery screening.
• Proteomics & Signal Transduction Studies: Employed to investigate protein-protein interactions and cellular signaling pathways.
• Custom Peptide Synthesis: A fundamental component for contract research organizations (CROs) and CDMOs producing custom peptides for clients.
• Academic Research: Supports fundamental studies in organic chemistry, medicinal chemistry, and peptide science at universities and institutes.

Basic Information

Product Name	Glycyl-Glycyl-Tyrosyl(o-Benzyl)-Arginine
CAS No.	29291-34-7
Molecular Formula	C30H41N7O6
Molecular Weight	595.69 g/mol
Synonyms	GGY(o-Bzl)R; H-Gly-Gly-Tyr(Bzl)-Arg-OH; Gly-Gly-Tyr(Bzl)-Arg; Tetrapeptide GGY(Bzl)R; N-(N-(N-(N2-[(Benzyloxy)carbonyl]-N6-(diaminomethylidene)lysyl)glycyl)glycyl)-O-benzyltyrosine; Boc-Gly-Gly-Tyr(Bzl)-Arg-OH (when using Boc protection strategy); Fmoc-Gly-Gly-Tyr(Bzl)-Arg-OH (when using Fmoc protection strategy)
EINECS	Contact for details

Quality Control

Our Glycyl-Glycyl-Tyrosyl(o-Benzyl)-Arginine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and residual solvent levels are provided with every shipment. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.