Description

Lofendazam is a high-purity benzodiazepine derivative with the CAS registry number 29176-29-2. This compound is valued for its specific pharmacological profile and serves as a crucial intermediate in advanced pharmaceutical research and development. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents within the central nervous system (CNS) domain.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in preclinical and pharmacological studies to investigate structure-activity relationships (SAR) and receptor binding profiles.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in laboratories.
• Chemical Synthesis: Employed in organic synthesis for the preparation of more complex molecules with potential biological activity.

Basic Information

Product Name	Lofendazam
CAS No.	29176-29-2
Molecular Formula	C₁₆H₁₂ClN₃O₂
Molecular Weight	313.74 g/mol
Synonyms	7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one; Lofendazamum; Ro 05-3590; CB-8133; LGD-8133; 1-Methyl-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
EINECS	Contact for details

Quality Control

Our Lofendazam is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via techniques such as HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.