Description

Ac-Lys-D-Ala-D-Ala-Oh is a synthetic tripeptide derivative featuring an acetylated lysine residue followed by two D-alanine units. This compound serves as a crucial biochemical tool and a key intermediate in advanced pharmaceutical research, particularly in studies related to bacterial cell wall synthesis and antibiotic resistance mechanisms. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in peptidomimetic drug discovery and microbiological studies.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study bacterial transpeptidases and penicillin-binding proteins (PBPs).
• Antibiotic Development: Serves as a key intermediate in the synthesis and study of novel glycopeptide and β-lactam antibiotics targeting cell wall biosynthesis.
• Peptide Chemistry: Acts as a building block for the solid-phase or solution-phase synthesis of more complex peptide sequences and peptidomimetics.
• Microbiology Studies: Employed in research investigating the mechanisms of vancomycin and related antibiotic resistance in bacteria.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Ac-Lys-D-Ala-D-Ala-Oh
CAS No.	28845-97-8
Molecular Formula	C16H29N5O6
Molecular Weight	387.43 g/mol
Synonyms	Acetyl-L-lysyl-D-alanyl-D-alanine; Nα-Acetyl-L-lysyl-D-alanyl-D-alanine; Ac-L-Lys-D-Ala-D-Ala; Acetyllysylalanylalanine; N-Acetyl-L-lysine-D-alanine-D-alanine; UDP-MurNAc-pentapeptide precursor analog; Peptide inhibitor of transpeptidase; (2R)-2-[[(2R)-2-[[(2S)-6-amino-2-(acetylamino)hexanoyl]amino]propanoyl]amino]propanoic acid
EINECS	Contact for details

Quality Control

Our Ac-Lys-D-Ala-D-Ala-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting the results against our stringent in-house specifications. Our commitment to quality and traceability ensures material consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-Ala)
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.