Description

H-Cys(Acm)-Oh Hcl is a protected cysteine derivative, specifically S-acetamidomethyl-L-cysteine hydrochloride. This compound is a crucial building block in peptide synthesis, where it serves to protect the thiol group of cysteine from unwanted side reactions during the coupling process. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for the development of therapeutic peptides and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled incorporation of cysteine into peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical peptide coupling methodologies for research-scale and industrial production.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: The Acm-protected thiol can be selectively deprotected for site-specific labeling or cross-linking applications.
• Biochemical Research: Employed in studies of protein structure, function, and disulfide bond formation.
• Ligand and Probe Development: Used to create cysteine-containing molecules for diagnostic and imaging applications.

Basic Information

Product Name	H-Cys(Acm)-Oh Hcl
CAS No.	28798-28-9
Molecular Formula	C5H11ClN2O3S
Molecular Weight	214.67 g/mol
Synonyms	S-Acetamidomethyl-L-cysteine hydrochloride; L-Cysteine, S-(acetamidomethyl)-, hydrochloride; Acm-Cys-OH·HCl; N-Acetamidomethyl-L-cysteine hydrochloride; Fmoc-Cys(Acm)-OH (related derivative); Boc-Cys(Acm)-OH (related derivative); S-(Acm)-Cysteine hydrochloride; (2R)-2-Amino-3-[[(2-acetamidoethyl)sulfanyl]methyl]-3-oxopropanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our H-Cys(Acm)-Oh Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: Specific range available on COA
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.