Description

2-(Perfluorophenyl)Acetaldehyde is a high-value fluorinated aromatic building block characterized by its reactive aldehyde functional group attached to a perfluorinated phenyl ring. This unique structure makes it an essential intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced stability, lipophilicity, and electronic properties are required. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex fluorinated molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides, where the fluorine atoms improve biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing charge transport and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart oil, water, and chemical resistance, and to lower dielectric constants.
• Cross-coupling Reactions: The aldehyde group is a versatile handle for further functionalization via reactions like reductive amination or Grignard additions.
• Ligand & Catalyst Development: Used to prepare fluorinated ligands for catalysis, which can significantly alter metal center reactivity and selectivity.

Basic Information

Item	Details
Product Name	2-(Perfluorophenyl)Acetaldehyde
CAS No.	28520-18-5
Molecular Formula	C8HF5O
Molecular Weight	208.08 g/mol
Synonyms	Pentafluorophenylacetaldehyde; 2,3,4,5,6-Pentafluorophenylacetaldehyde; α-Oxo-2,3,4,5,6-pentafluorotoluene; Perfluorophenylacetaldehyde; (2,3,4,5,6-Pentafluorophenyl)acetaldehyde; 2-(2,3,4,5,6-Pentafluorophenyl)ethanal; 28520-18-5; PFP-acetaldehyde
EINECS	Contact for details

Quality Control

Our 2-(Perfluorophenyl)Acetaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.