Description

Z-Phe-His-Leu-Oh CAS NO 28458-19-7 is a synthetic tripeptide derivative, specifically a protected peptide sequence, widely used as a key intermediate in advanced pharmaceutical research and peptide synthesis. This compound is crucial for the development of enzyme inhibitors and for studying protease activity, particularly in relation to angiotensin-converting enzyme (ACE). It serves as an essential building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity, well-characterized peptide fragments.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of more complex therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays, particularly for studying angiotensin-converting enzyme (ACE) and other metalloproteases.
• Protease Activity Studies: Essential for investigating the kinetics and mechanisms of protease enzymes in academic and industrial research settings.
• Peptide Library Construction: Serves as a defined sequence unit in the combinatorial synthesis of peptide libraries for drug discovery.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in peptide analysis.
• Medicinal Chemistry: Utilized in structure-activity relationship (SAR) studies to design and optimize new drug candidates.

Basic Information

Product Name	Z-Phe-His-Leu-Oh
CAS No.	28458-19-7
Molecular Formula	C30H37N5O6
Molecular Weight	563.65 g/mol
Synonyms	Z-Phe-His-Leu-OH; N-Benzyloxycarbonyl-L-phenylalanyl-L-histidyl-L-leucine; Z-Phe-His-Leu; CBZ-Phe-His-Leu-OH; N-CBZ-L-Phenylalanyl-L-Histidyl-L-Leucine; Z-F-H-L-OH; (S)-2-((S)-2-((((Benzyloxy)carbonyl)amino)-3-phenylpropanamido)-3-(1H-imidazol-4-yl)propanamido)-4-methylpentanoic acid; Nα-Carbobenzoxy-L-phenylalanyl-L-histidyl-L-leucine
EINECS	Contact for details

Quality Control

Our Z-Phe-His-Leu-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, MS). A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients in regulatory submissions and critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.