Description

Thyrotropin-Releasing Hormone, β-(Pyrazolyl-1)-Ala(2)- is a synthetic analog of the endogenous thyrotropin-releasing hormone (TRH), featuring a pyrazolyl-alanine substitution. This modification is designed to enhance metabolic stability and receptor binding affinity, making it a valuable research tool for studying neuroendocrine pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on endocrinology, neuroscience, and peptide drug discovery.

Application

• Neuroendocrine Research: Used as a potent and stable agonist to investigate the hypothalamic-pituitary-thyroid (HPT) axis and TRH receptor signaling.
• Pharmacological Studies: Serves as a reference standard in assays to screen for TRH receptor modulators and evaluate peptide stability.
• Neuroscience & Behavioral Studies: Applied in research exploring the role of TRH in CNS functions, including arousal, thermoregulation, and potential antidepressant effects.
• Peptide Chemistry & Drug Development: Acts as a key intermediate or model compound for developing novel peptide-based therapeutics with improved pharmacokinetic profiles.
• Diagnostic Tool Development: Employed in the development of immunoassays and other diagnostic methods for thyroid function and related disorders.

Basic Information

Product Name	Thyrotropin-Releasing Hormone, β-(Pyrazolyl-1)-Ala(2)-
CAS No.	28398-28-9
Molecular Formula	C16H23N7O4
Molecular Weight	377.40 g/mol
Synonyms	TRH, Pyrazolyl-Ala(2)-TRH; Pyroglutamyl-Histidyl-(3-(1H-Pyrazol-1-yl))-Alaninamide; β-(1-Pyrazolyl)-Ala(2)-TRH; (Pyrazolyl-1)-Ala2-Thyroliberin; TRH Analog; L-Pyroglutamyl-L-histidyl-3-(1H-pyrazol-1-yl)-L-alaninamide
EINECS	Contact for details

Quality Control

Our Thyrotropin-Releasing Hormone, β-(Pyrazolyl-1)-Ala(2)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.