Description

Boc-Gly-Gly-Gly-Oh (CAS NO 28320-73-2) is a protected tripeptide building block featuring a tert-butoxycarbonyl (Boc) N-terminal protecting group. This compound is essential for the solid-phase and solution-phase synthesis of more complex peptides, offering excellent orthogonality in multi-step synthetic strategies. It is a critical raw material for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require high-purity, reliable peptide fragments.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of therapeutic peptides and peptidomimetics.
• Bioconjugation: Used to introduce a glycine-rich linker or spacer arm in the synthesis of antibody-drug conjugates (ADCs) and other bioconjugates.
• Biochemical Research: Serves as a standard or substrate in enzymatic studies, particularly for proteases and peptidases.
• Material Science: A precursor for creating bio-inspired polymers and peptide-based hydrogels with tailored properties.
• Combinatorial Chemistry: A valuable scaffold in library synthesis for drug discovery and high-throughput screening.

Basic Information

Product Name	Boc-Gly-Gly-Gly-Oh
CAS No.	28320-73-2
Molecular Formula	C₁₂H₂₁N₃O₆
Molecular Weight	303.31 g/mol
Synonyms	Boc-Gly-Gly-Gly-OH; N-(tert-Butoxycarbonyl)glycylglycylglycine; Glycylglycylglycine, N-[(1,1-dimethylethoxy)carbonyl]-; Boc-GGG-OH; tert-Butyloxycarbonyl-Gly-Gly-Gly; N-Boc-triglycine; (2-{2-[(2-{[(tert-Butoxy)carbonyl]amino}acetyl)amino]acetylamino}acetic acid)
EINECS	Contact for details

Quality Control

Our Boc-Gly-Gly-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available upon request to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.