Description

β-Methylnorleucine is a non-proteinogenic amino acid derivative of significant interest in advanced chemical synthesis and pharmaceutical research. Its unique structural features, including the β-methyl substitution on the norleucine backbone, make it a valuable chiral building block for the development of novel peptide-based therapeutics and bioactive compounds. This high-purity intermediate is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, proteomics, and the development of enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide drugs and enzyme inhibitors.
• Medicinal Chemistry: Used as a building block for structure-activity relationship (SAR) studies and the synthesis of constrained peptide analogs.
• Biochemical Research: Employed in proteomics and metabolic pathway studies as a non-natural amino acid probe.
• Peptide Synthesis: Serves as a specialized monomer in solid-phase and solution-phase peptide synthesis to introduce specific steric and functional properties.
• Agrochemical Research: Potential intermediate in the development of novel, bioactive compounds for crop protection.

Basic Information

Product Name	β-Methylnorleucine
CAS No.	28116-92-9
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	(2R)-2-Amino-4-methylhexanoic acid; (R)-2-Amino-4-methylhexanoic acid; D-β-Methylnorleucine; (R)-β-Methylnorleucine; H-β-MeNle-OH; 4-Methyl-D-norleucine; (2R)-2-Amino-4-methyl-caproic acid; β-Methyl-D-norleucine
EINECS	Contact for details

Quality Control

Our β-Methylnorleucine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Specific Rotation	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.