Description

(2S,3R)-2-Amino-3-Methylhexanoic Acid CAS NO 28116-85-0 is a high-purity, non-proteinogenic amino acid characterized by its specific stereochemistry at the 2 and 3 carbon positions. This compound is a critical chiral building block in the synthesis of complex pharmaceuticals and bioactive peptides, where precise stereochemistry is essential for biological activity and efficacy. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in metabolic and neurological disorder research.
• Peptide Synthesis: Used as a constrained, non-natural amino acid residue in the design and solid-phase synthesis of therapeutic and diagnostic peptides to modulate stability and receptor binding.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and metabolic pathway analysis due to its specific stereoconfiguration.
• Asymmetric Catalysis: Employed as a chiral ligand or auxiliary in asymmetric synthesis to induce stereoselectivity in carbon-carbon bond-forming reactions.
• Nutraceutical Development: Investigated for potential use in specialized nutritional supplements and fortified products targeting specific metabolic functions.

Basic Information

Product Name	(2S,3R)-2-Amino-3-Methylhexanoic Acid
CAS No.	28116-85-0
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	(2S,3R)-2-Amino-3-methylhexanoic acid; (2S,3R)-3-Methyl-2-aminocaproic acid; D-*threo*-3-Methylisoleucine; (2S,3R)-3-Methylisoleucine; 3-Methyl-L-isoleucine; (2S,3R)-2-Amino-3-methylcaproic acid; 2-Amino-3-methylhexanoic acid (specific isomer)
EINECS	Contact for details

Quality Control

Our (2S,3R)-2-Amino-3-Methylhexanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, assay, chiral purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.