Description

Poly-N(5)-(2-Hydroxyethyl)Glutamine is a synthetic polyamino acid derivative, specifically a polymer of N(5)-(2-hydroxyethyl)-L-glutamine. This compound is valued for its biocompatibility, water solubility, and functional hydroxyl groups, making it a versatile building block for advanced materials. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biomedical, and specialty polymer industries for applications ranging from drug delivery systems to hydrogel formulations.

Application

• Biomedical Hydrogels: Serves as a key monomer or cross-linkable polymer for creating biocompatible and biodegradable hydrogels used in tissue engineering scaffolds and wound dressings.
• Drug Delivery Carriers: Utilized in the synthesis of polymeric micelles, nanoparticles, or conjugates for the controlled and targeted release of therapeutic agents.
• Protein & Peptide Modification: Acts as a polymeric carrier or spacer to enhance the stability, solubility, or pharmacokinetic profile of bioactive peptides and proteins.
• Cosmetic & Personal Care Formulations: Incorporated as a film-forming agent, moisturizer, or viscosity modifier in high-performance skincare products.
• Bioink Component: Used in the development of bio-inks for 3D bioprinting applications due to its favorable rheological and cell-interactive properties.
• Chromatography Media: Can be grafted onto solid supports to create hydrophilic interaction chromatography (HILIC) stationary phases for biomolecule separation.

Basic Information

Product Name	Poly-N(5)-(2-Hydroxyethyl)Glutamine
CAS No.	27878-59-7
Molecular Formula	(C7H12N2O4)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly[N5-(2-Hydroxyethyl)-L-glutamine]; Poly(HEG); PHEG; Poly(N5-hydroxyethyl L-glutamine); Poly(hydroxyethylglutamine); Poly[N5-(2-hydroxyethyl)glutamine]; L-Glutamine, N5-(2-hydroxyethyl)-, homopolymer
EINECS	Contact for details

Quality Control

Our Poly-N(5)-(2-Hydroxyethyl)Glutamine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure consistency in molecular weight distribution, purity, and functional group integrity. Certificates of Analysis (COA) detailing specifications such as degree of polymerization, residual solvent levels, and endotoxin content (where applicable) are provided to support research and cGMP manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions or under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (NMR/HPLC)	≥ 95% (Polymer content)
Molecular Weight (GPC)	Specified range available (e.g., 5kDa - 50kDa)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Endotoxin (LAL)	< 0.25 EU/mg (for biomedical grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.