Description

Trt-Cys(Trt)-Oh CAS NO 27686-50-6 is a protected cysteine derivative, a crucial building block in solid-phase peptide synthesis (SPPS). Its primary value lies in the dual trityl (Trt) protecting groups, which safeguard the thiol and amino functionalities, enabling selective deprotection and controlled peptide chain assembly. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, biotechnology, and advanced materials science who require precise molecular control for creating complex peptides and peptide-based therapeutics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-strategy building block for the controlled incorporation of cysteine residues into peptide sequences.
• Pharmaceutical Intermediates: Used in the research and production of therapeutic peptides, including hormones, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation & Protein Engineering: Serves as a precursor for introducing thiol-reactive sites or disulfide bridges to modify proteins, antibodies, or other biomolecules.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for studying protein-protein interactions, enzyme activity, and cellular processes.
• Material Science: Used to create peptide-based polymers, hydrogels, or surface coatings where cysteine's properties are required.
• Custom Peptide Services: A key raw material for CROs and CDMOs offering bespoke peptide synthesis for academic and industrial clients.

Basic Information

Product Name	Trt-Cys(Trt)-Oh
CAS No.	27686-50-6
Molecular Formula	C39H34N2O2S
Molecular Weight	594.76 g/mol
Synonyms	S-Trityl-L-cysteine Trityl Ether; Nα-Trityl-S-trityl-L-cysteine; Fmoc-Cys(Trt)-OH precursor; L-Cysteine, N-(triphenylmethyl)-, S-(triphenylmethyl) ether; N-Trityl-S-tritylcysteine; N,S-Ditrityl-L-cysteine; Protected Cysteine Derivative; SPPS Cysteine Building Block
EINECS	Contact for details

Quality Control

Our Trt-Cys(Trt)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Specific range available on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.