Description

n-(Benzyloxycarbonyl)-L-Thr-L-Ala-L-Leu-L-Leu-Gly-Ome is a synthetic pentapeptide derivative, where the N-terminus is protected by a benzyloxycarbonyl (Z or Cbz) group and the C-terminus is methylated. This compound is a crucial protected peptide intermediate used in solid-phase and solution-phase peptide synthesis (SPPS), enabling the controlled elongation of peptide chains. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical research tools.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of longer, biologically active peptide sequences for drug discovery and development.
• Peptide Synthesis Research: Used in academic and industrial research for studying peptide coupling methodologies, protecting group strategies, and structure-activity relationships (SAR).
• Bioconjugation & Probe Development: Acts as a precursor for creating labeled peptides or peptide-based probes used in diagnostic assays and imaging studies.
• Enzyme Substrate Analog: Can be utilized in biochemical assays to study the specificity and kinetics of proteases and other enzymes that recognize peptide sequences.
• Custom Peptide Manufacturing: An essential raw material for contract research and manufacturing organizations (CROs/CMOs) producing custom peptides at milligram to kilogram scales.

Basic Information

Item	Detail
Product Name	n-(Benzyloxycarbonyl)-L-Thr-L-Ala-L-Leu-L-Leu-Gly-Ome
CAS No.	27545-13-7
Molecular Formula	C31H49N5O9
Molecular Weight	635.75 g/mol
Synonyms	Cbz-Thr-Ala-Leu-Leu-Gly-OMe; Z-Thr-Ala-Leu-Leu-Gly-OMe; Benzyloxycarbonyl-L-threonyl-L-alanyl-L-leucyl-L-leucylglycine methyl ester; N-[(Benzyloxy)carbonyl]-L-threonyl-L-alanyl-L-leucyl-L-leucylglycine methyl ester; Cbz-T-A-L-L-G-OMe; Protected TALLG peptide; Pentapeptide derivative Cbz-TALLG-OMe
EINECS	Contact for details

Quality Control

Our n-(Benzyloxycarbonyl)-L-Thr-L-Ala-L-Leu-L-Leu-Gly-Ome is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure enantiomeric integrity. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee batch-to-batch consistency and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere (argon or nitrogen) after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.