Description

H-Val-Ala-Oh is a high-purity dipeptide building block, specifically the C-terminal carboxylic acid derivative of the Val-Ala sequence. This compound is essential for advanced peptide synthesis and pharmaceutical research, offering precise control over molecular structure. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Protease Substrate Analog: Used in biochemical research to study enzyme kinetics, specificity, and inhibition, particularly for proteases that cleave at valine and alanine residues.
• Bioconjugation: Serves as a spacer or linker molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates due to its terminal carboxylic acid group.
• Peptide Library Construction: Employed in combinatorial chemistry for generating diverse peptide libraries for drug discovery and screening purposes.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development and quality control of peptide products.
• Biomaterial Research: Incorporated into designed peptide sequences for creating functional hydrogels, surface coatings, and other advanced biomaterials.

Basic Information

Product Name	H-Val-Ala-Oh
CAS No.	27493-61-4
Molecular Formula	C8H16N2O3
Molecular Weight	188.22 g/mol
Synonyms	L-Valyl-L-alanine; Val-Ala; V-A; H-Val-Ala-OH; L-Val-L-Ala; N-(2-Methylpropyl)-L-alanine; L-Alanine, N-L-valyl-; (2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]propanoic acid
EINECS	Contact for details

Quality Control

Every batch of H-Val-Ala-Oh is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA), including results for assay, chiral purity, and related substances by HPLC, is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-L isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.