Description

S-(1-Menaphthyl)Glutathione is a specialized biochemical conjugate formed by the reaction of glutathione with 1-menaphthyl, a derivative of vitamin K. This compound is significant as a model substrate and a key intermediate in the study of glutathione S-transferase (GST) enzyme activity and detoxification pathways. It is primarily utilized by research institutions and pharmaceutical developers focused on enzymology, metabolic studies, and the development of biochemical assays.

Application

• Biochemical Research: Serves as a critical substrate for investigating the kinetics and mechanism of Glutathione S-Transferase (GST) enzymes.
• Enzyme Assay Development: Used in the development and validation of high-throughput screening assays for GST activity and inhibition studies.
• Metabolic Pathway Analysis: Acts as a tool compound to study Phase II biotransformation and detoxification processes in cellular and in vitro models.
• Pharmaceutical Intermediates: Potential use as a synthetic intermediate or reference standard in the development of novel therapeutic agents.
• Toxicology Studies: Employed in research to understand cellular defense mechanisms against electrophilic toxins and oxidative stress.

Basic Information

Product Name	S-(1-Menaphthyl)Glutathione
CAS No.	27321-05-7
Molecular Formula	C₂₀H₂₅N₃O₆S
Molecular Weight	435.49 g/mol
Synonyms	S-(1-Menaphthyl)glutathione; 1-Menaphthyl glutathione; γ-Glutamylcysteinylglycine S-(1-menaphthyl) ester; Glutathione S-(1-menaphthyl) conjugate; GST substrate analog; NSC 401005; L-γ-Glutamyl-L-cysteinylglycine S-ester with 1-hydroxy-4-methyl-2-naphthoic acid 1-sulfate
EINECS	Contact for details

Quality Control

Our S-(1-Menaphthyl)Glutathione is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the exacting standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The product is moisture-sensitive; keep the container tightly sealed in a cool, dry place.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.