Description

4-Methyl-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its ability to act as a versatile electrophilic reagent for introducing the sulfonamide moiety, enabling the development of novel compounds with targeted properties. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the sulfonamide group is a common pharmacophore.
• Dye and Pigment Manufacturing: Serves as an intermediate for creating specialized sulfonamide-based dyes and colorants with enhanced properties.
• Polymer Chemistry: Employed in the synthesis of functional monomers and polymers, contributing to materials with specific chemical resistance or surface characteristics.
• Chemical Research & Development: A valuable tool for medicinal and process chemists in structure-activity relationship (SAR) studies and lead optimization.
• Ligand and Catalyst Design: Used to prepare specialized sulfonamide-containing ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	4-Methyl-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Sulfonyl Chloride
CAS No.	27320-81-6
Molecular Formula	C9H8ClNO4S
Molecular Weight	261.68 g/mol
Synonyms	4-Methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-sulfonyl chloride; 2H-1,4-Benzoxazine-6-sulfonyl chloride, 3,4-dihydro-4-methyl-3-oxo-; 6-(Chlorosulfonyl)-4-methyl-2H-1,4-benzoxazin-3(4H)-one; 4-Methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonyl chloride; 3,4-Dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-6-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Methyl-3-Oxo-3,4-Dihydro-2H-Benzo[B][1,4]Oxazine-6-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.