Description

5-Chloro-2,4-Difluoro-6-Methoxypyrimidine is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its unique halogenated pyrimidine structure, which serves as a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS-targeted drug discovery programs.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging its halogenated pyrimidine core.
• Material Science Research: Used in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its electron-deficient aromatic system.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the scalable production of client-specific target molecules.
• Academic & Industrial R&D: A valuable reagent for methodological studies in cross-coupling reactions, nucleophilic aromatic substitution, and other halogen-exchange chemistries.

Basic Information

Product Name	5-Chloro-2,4-Difluoro-6-Methoxypyrimidine
CAS No.	27265-89-0
Molecular Formula	C5H3ClF2N2O
Molecular Weight	180.54 g/mol
Synonyms	6-Methoxy-5-chloro-2,4-difluoropyrimidine; 2,4-Difluoro-5-chloro-6-methoxypyrimidine; 5-Chloro-2,4-difluoro-6-methoxypyrimidine; Pyrimidine, 5-chloro-2,4-difluoro-6-methoxy-; 27265-89-0; 5-Chloro-2,4-difluoro-6-methoxypyrimidine (CAS 27265-89-0)
EINECS	Contact for details

Quality Control

Our 5-Chloro-2,4-Difluoro-6-Methoxypyrimidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.