Description

4,4'-Difluorodiphenylmethylchloride is a key fluorinated aromatic intermediate of significant commercial importance. Its value lies in its reactive benzyl chloride and difluorophenyl groups, making it a versatile building block for advanced synthesis. This compound is primarily needed by manufacturers in the pharmaceutical, agrochemical, and specialty polymer industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluorophenyl moiety enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), improving performance and durability.
• Polymer & Resin Modifier: Incorporated into specialty polymers, such as polyarylates and epoxy resins, to enhance thermal stability, chemical resistance, and dielectric properties.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for creating complex biaryl structures in research and development.
• Ligand & Catalyst Preparation: Utilized in the synthesis of specialized ligands and organocatalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	4,4'-Difluorodiphenylmethylchloride
CAS No.	27064-94-4
Molecular Formula	C13H9ClF2
Molecular Weight	238.66 g/mol
Synonyms	1-(Chloromethyl)-4-(4-fluorophenyl)benzene; 4,4'-Difluorobenzhydryl Chloride; α-Chloro-4,4'-difluorotoluene; (4-Fluorophenyl)(4-fluorophenyl)methyl Chloride; 4,4'-Difluorobenzhydryl Chloride; 4,4'-Difluorodiphenylchloromethane; p,p'-Difluorobenzhydryl Chloride; Benzhydryl chloride, 4,4'-difluoro-
EINECS	Contact for details

Quality Control

Our 4,4'-Difluorodiphenylmethylchloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for fine chemical synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the light-sensitive nature of this compound, containers should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.