Description

Alamethicinresearch Grade is a high-purity, synthetic peptide antibiotic belonging to the peptaibol family, widely recognized for its ability to form voltage-gated ion channels in lipid membranes. This research-grade material is essential for fundamental studies in membrane biophysics, electrophysiology, and antimicrobial mechanisms. It is a critical tool for researchers and scientists in the pharmaceutical, biotechnology, and academic sectors investigating ion transport, pore-forming agents, and novel antibiotic strategies.

Application

• Membrane Biophysics Research: Primary tool for studying the formation and properties of voltage-gated ion channels in artificial lipid bilayers and cell membranes.
• Electrophysiology Studies: Used in patch-clamp and planar lipid bilayer experiments to investigate single-channel conductance and ion selectivity.
• Antimicrobial Mechanism Research: Serves as a model compound for understanding the action of pore-forming peptides against bacteria, fungi, and other microorganisms.
• Drug Delivery System Development: Investigated as a potential component in novel drug delivery platforms that utilize membrane-disrupting properties.
• Biochemical Assays: Employed in assays designed to screen for compounds that modulate ion channel activity or membrane integrity.
• Academic & Pharmaceutical R&D: Fundamental research reagent in university laboratories and pharmaceutical R&D departments for target validation and basic science.

Basic Information

Product Name	Alamethicinresearch Grade
CAS No.	27061-78-5
Molecular Formula	C92H150N22O25
Molecular Weight	1964.3 g/mol
Synonyms	Alamethicin; Antibiotic U-22324; Peptaibol Alamethicin I; NSC 326223; L-Aib-L-Aib-L-Aib-L-Ala-L-Aib-L-Ala-L-Aib-L-Aib-L-Aib-L-Aib-L-Gln-L-Aib-L-Val-L-Aib-L-Gly-L-Leu-L-Aib-L-Pro-L-Val-L-Aib-L-Aib-L-Glu-Gln-Phol
EINECS	Contact for details

Quality Control

Our Alamethicinresearch Grade is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and chromatographic profile. We adhere to high standards suitable for research use, ensuring the material meets the stringent requirements of analytical and life science laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Peptide Content	≥ 80%
Solubility	Soluble in ethanol, methanol, DMSO; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.