Description

Pglu-L-His-L-Phe-Nh2 CAS NO 27058-75-9 is a synthetic tripeptide derivative, specifically pyroglutamyl-histidyl-phenylalanine amide. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a precursor or model structure for studying peptide stability, receptor interactions, and enzymatic processes. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in advanced peptide synthesis and drug discovery programs.

Application

• Pharmaceutical Research: Serves as a key intermediate or reference standard in the development of novel peptide-based therapeutics and diagnostic agents.
• Biochemical Studies: Used as a substrate or inhibitor model for investigating enzyme kinetics, particularly those involving histidine or phenylalanine residues.
• Cosmetic Science: Potential application in the research and development of bioactive peptides for advanced skincare formulations targeting specific cellular pathways.
• Academic Research: Employed in university and institutional labs for fundamental studies on peptide conformation, stability, and structure-activity relationships (SAR).
• Process Development: Acts as a building block or model compound for optimizing synthetic routes and purification processes in peptide manufacturing.

Basic Information

Product Name	Pglu-L-His-L-Phe-Nh2
CAS No.	27058-75-9
Molecular Formula	C20H24N6O4
Molecular Weight	412.45 g/mol
Synonyms	Pyroglutamyl-histidyl-phenylalanine amide; Pyroglutamyl-L-histidyl-L-phenylalaninamide; L-Pyroglutamyl-L-histidyl-L-phenylalaninamide; pGlu-His-Phe-NH2; TRH-related peptide; Thyrotropin-releasing hormone analog; pGlu-His-Phe amide; 5-Oxo-L-prolyl-L-histidyl-L-phenylalaninamide
EINECS	Contact for details

Quality Control

Our Pglu-L-His-L-Phe-Nh2 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the results against our stringent in-house specifications. We support cGMP-compliant manufacturing for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 2.0%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.