Description

Pglu-His-Gly Amide is a synthetic tripeptide derivative, specifically the C-terminal amide of the pyroglutamyl-histidyl-glycine sequence. This compound is a valuable biochemical building block and research tool, offering a stable amide terminus for peptide synthesis and structural studies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in peptide chemistry, drug discovery, and biochemical assay development.

Application

• Peptide Synthesis Intermediate: Serves as a key building block for the solid-phase or solution-phase synthesis of longer, more complex peptide chains.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies, particularly those involving peptidases or amidases.
• Drug Discovery: Acts as a core structure or pharmacophore for the development of novel therapeutic agents targeting neurological or metabolic pathways.
• Neuroscience Studies: Investigated for potential biological activity related to its pyroglutamate and histidine residues, which are found in various neuropeptides.
• Cosmetic Peptide Research: Explored in the development of bioactive peptides for skincare formulations due to its structural components.

Basic Information

Item	Details
Product Name	Pglu-His-Gly Amide
CAS No.	27058-74-8
Molecular Formula	C14H20N6O4
Molecular Weight	336.35 g/mol
Synonyms	Pyroglutamyl-Histidyl-Glycinamide; pGlu-His-Gly-NH2; L-Pyroglutamyl-L-histidyl-glycine amide; 5-Oxo-L-prolyl-L-histidylglycinamide; TRH Fragment (1-3) Amide; Thyrotropin-Releasing Hormone (1-3) Amide; pGlu-His-Gly-NH2; L-pGlu-L-His-Gly-NH2
EINECS	Contact for details

Quality Control

Our Pglu-His-Gly Amide is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0% (Total Peptide Content)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.