Description

Pglu-L-His-L-Val-NH2 is a synthetic tripeptide derivative, specifically a pyroglutamyl-histidyl-valinamide. This compound is of significant interest in pharmaceutical research and development due to its role as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of more complex therapeutic peptides. It is primarily utilized by research institutions, pharmaceutical manufacturers, and biotechnology companies engaged in the development of novel peptide-based drugs, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the solid-phase or solution-phase synthesis of larger, therapeutically relevant peptide sequences.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies, receptor binding assays, and metabolic pathway investigations.
• Drug Discovery: Acts as a core structure for the development and screening of new peptide analogs with potential biological activity.
• Cosmeceutical Development: Investigated for potential applications in advanced skincare formulations targeting specific biological pathways.
• Diagnostic Reagent Production: May be employed in the manufacture of specialized reagents for clinical diagnostics and immunoassays.

Basic Information

Product Name	Pglu-L-His-L-Val-NH2
CAS No.	27058-71-5
Molecular Formula	C17H26N6O4
Molecular Weight	378.43 g/mol
Synonyms	Pyroglutamyl-histidyl-valinamide; L-Pyroglutamyl-L-histidyl-L-valinamide; pGlu-His-Val-NH2; TRH Free Acid; Thyrotropin-Releasing Hormone Free Acid; (S)-5-Oxo-1-((S)-1-((S)-1-amino-3-methyl-1-oxobutan-2-yl)amino)-1-oxo-3-(1H-imidazol-5-yl)propan-2-yl)pyrrolidine-2-carboxamide; Proglumide analog
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of Pglu-L-His-L-Val-NH2 is characterized and tested against stringent in-house specifications to guarantee identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.