Description

n-[S-Trityl-L-Cysteinyl]Glycine CAS NO 26988-61-4 is a protected cysteine derivative peptide, widely utilized as a crucial building block in solid-phase peptide synthesis (SPPS). Its primary value lies in the S-trityl protecting group, which offers orthogonal protection for the thiol side chain of cysteine, enabling selective deprotection and the formation of disulfide bonds in complex peptide sequences. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the controlled assembly of peptide chains, particularly those containing cysteine residues.
• Pharmaceutical Intermediates: Serves as a critical raw material in the research and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Disulfide Bond Formation: The S-trityl group allows for the precise and sequential formation of intramolecular and intermolecular disulfide bridges, which are vital for the tertiary structure and biological activity of many peptides.
• Bioconjugation Chemistry: Used in the synthesis of peptide-protein conjugates, peptide-drug conjugates, and other labeled biomolecules where site-specific cysteine modification is required.
• Biochemical Research: Employed in academic and industrial laboratories for studying protein folding, enzyme mechanisms, and receptor-ligand interactions.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	n-[S-Trityl-L-Cysteinyl]Glycine
CAS No.	26988-61-4
Molecular Formula	C24H22N2O3S
Molecular Weight	418.51 g/mol
Synonyms	N-[(S)-Triphenylmethyl-L-cysteinyl]glycine; Fmoc-Cys(Trt)-Gly-OH (Note: This is a common related derivative); S-Trityl-L-cysteine-glycine; Glycine, N-[(S)-triphenylmethyl-L-cysteinyl]-; L-Cysteine, N-(carboxymethyl)-, S-(triphenylmethyl)-; S-Tritylcysteinylglycine; N-(S-Trityl-L-cysteinyl)glycine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tritylthio)propanoic acid (related Fmoc derivative)
EINECS	Contact for details

Quality Control

Our n-[S-Trityl-L-Cysteinyl]Glycine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation to maintain optimal quality and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.