Description

Boc-Cys(Trt)-Oh Dcha CAS NO 26988-59-0 is a protected cysteine derivative, specifically the N-Boc, S-trityl protected form of L-cysteine as a dicyclohexylamine (DCHA) salt. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where it provides orthogonal protection for the thiol group, preventing unwanted side reactions during chain assembly. It is an essential raw material for researchers and manufacturers in pharmaceutical development, biotechnology, and peptide chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled incorporation of cysteine into peptide sequences.
• Pharmaceutical Intermediates: Used in the synthesis of therapeutic peptides and peptidomimetics targeting various diseases.
• Bioconjugation Chemistry: Serves as a precursor for introducing thiol-reactive handles or disulfide bonds into biomolecules.
• Research & Development: A standard reagent in academic and industrial labs for exploring peptide structure-activity relationships.
• Production of Cysteine-Containing Peptides: Essential for manufacturing peptides where the cysteine residue must be selectively deprotected for cyclization or labeling.

Basic Information

Product Name	Boc-Cys(Trt)-Oh Dcha
CAS No.	26988-59-0
Molecular Formula	C33H40N2O4S • C12H23N
Molecular Weight	663.93 g/mol (Free acid: 483.65 g/mol)
Synonyms	Boc-Cys(Trt)-OH DCHA salt; N-α-Boc-S-trityl-L-cysteine dicyclohexylamine salt; (2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-tritylsulfanylpropanoic acid - dicyclohexylamine (1:1); Boc-L-Cys(Trt)-OH • DCHA; Boc-S-trityl-L-cysteine DCHA salt; Boc-Cys(Trt)-OH dicyclohexylammonium salt; N-tert-Butoxycarbonyl-S-trityl-L-cysteine DCHA salt
EINECS	Contact for details

Quality Control

Our Boc-Cys(Trt)-Oh Dcha is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with full specifications are provided to guarantee batch-to-batch consistency and reliable performance in your applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.5%
Optical Rotation [α]	-15.0° to -18.0° (c=1 in DMF)
Melting Point	~158-162°C (dec.)
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.2%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.