Description

Poly-L-Arginine Hydrochloride is a cationic polypeptide derived from the amino acid L-arginine, widely recognized for its strong positive charge and biocompatibility. This compound is essential for applications requiring cell adhesion promotion, membrane permeability enhancement, and as a versatile building block in biomaterial science. It is a critical raw material for researchers and manufacturers in the pharmaceutical, biomedical, and cosmetic industries, where its polycationic nature is leveraged for drug delivery, tissue engineering, and advanced formulation development.

Application

• Biomedical Research & Cell Culture: Used as a coating agent to promote cell adhesion and growth on various substrates, facilitating in vitro studies.
• Drug Delivery Systems: Serves as a key component in the formulation of polyelectrolyte complexes and nanoparticles for controlled and targeted release of therapeutic agents.
• Tissue Engineering Scaffolds: Incorporated into hydrogels and 3D matrices to create bioactive environments that support tissue regeneration.
• Cosmetic & Personal Care: Utilized in advanced skincare formulations for its film-forming and moisturizing properties, as well as to enhance the penetration of active ingredients.
• Diagnostic Assays: Acts as an immobilization matrix for enzymes, antibodies, or DNA in biosensor and diagnostic kit development.
• Gene Transfection: Functions as a non-viral vector to condense and deliver nucleic acids into cells for genetic research and therapy.

Basic Information

Product Name	Poly-L-Arginine Hydrochloride
CAS No.	26982-20-7
Molecular Formula	(C6H14N4O2 • HCl)n
Molecular Weight	Varies by chain length (monomer MW: 210.66)
Synonyms	Poly(arginine hydrochloride); L-Arginine homopolymer hydrochloride; PArg HCl; Polyarginine HCl; Poly-L-Arg•HCl; (L-Arginine)n hydrochloride; Cationic poly(amino acid); Poly(α-L-arginine) hydrochloride
EINECS	Contact for details

Quality Control

Our Poly-L-Arginine Hydrochloride is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) that include data on molecular weight distribution, degree of polymerization, chloride content, and bioburden, as applicable. Our quality commitment supports compliance with cGMP and ISO standards for research and pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a low-humidity environment to prevent absorption of water.

Specification

Item	Specification
Appearance	White to off-white powder or fibrous solid
Identification (IR)	Conforms to structure
Assay (Nitrogen)	≥ 95.0%
Chloride Content	15.0% - 18.0%
Molecular Weight (Avg.)	5,000 - 15,000 Da (or as specified)
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 1.0%
Bioburden	≤ 100 CFU/g (for specific grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.