Description

H-Arg-Arg-Arg-Arg-OH is a synthetic tetrapeptide composed of four consecutive arginine amino acid residues. This oligoarginine sequence is of significant interest in biochemical and pharmaceutical research due to its potent cell-penetrating properties and strong cationic character. It serves as a critical tool compound for scientists in drug delivery, molecular biology, and proteomics. The product is supplied as a high-purity material suitable for research and development applications.

Application

• Cell-Penetrating Peptide (CPP) Research: Used as a model compound to study the mechanisms of cellular uptake and intracellular delivery of bioactive molecules.
• Drug Delivery Vector Development: Acts as a carrier to facilitate the transport of impermeable drugs, nucleic acids (siRNA, DNA), and proteins across cell membranes.
• Bioconjugation & Probe Synthesis: Serves as a building block for creating fluorescently labeled or otherwise tagged peptides for imaging and tracking studies.
• Enzyme Substrate & Inhibitor Studies: Utilized in biochemical assays to investigate the activity of proteases like trypsin or other arginine-specific enzymes.
• Material Science & Surface Modification: Employed to coat surfaces or nanoparticles to impart a positive charge and enhance biocompatibility or cellular adhesion.
• Standard & Reference Material: Provides a high-purity standard for analytical methods such as HPLC and mass spectrometry in peptide quality control.

Basic Information

Product Name	H-Arg-Arg-Arg-Arg-OH
CAS No.	26791-46-8
Molecular Formula	C₂₄H₅₂N₂₀O₅
Molecular Weight	669.78 g/mol
Synonyms	Tetraarginine; Arg-Arg-Arg-Arg; RRRR; H-Arg-Arg-Arg-Arg-OH acetate; Oligoarginine R4; Cell-penetrating peptide R4; L-Arginyl-L-arginyl-L-arginyl-L-arginine; Polyarginine (n=4)
EINECS	Contact for details

Quality Control

Every batch of H-Arg-Arg-Arg-Arg-OH is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (by MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Assay (Content)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	Contact for details
Single Impurity (HPLC)	≤ 1.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.