Description

H-γ-Abu-Obzl p-Tosylate is a protected amino acid derivative, specifically a γ-aminobutyric acid (GABA) analog with a benzyl ester and p-toluenesulfonate salt group. This compound serves as a crucial pharmaceutical intermediate and building block in advanced organic synthesis, enabling the controlled introduction of the GABA moiety into more complex molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of neuroactive compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel GABAergic drugs and central nervous system (CNS) active compounds.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide chemistry to incorporate modified γ-aminobutyric acid residues.
• Medicinal Chemistry Research: Serves as a precursor for structure-activity relationship (SAR) studies targeting GABA receptors.
• Prodrug Development: Utilized in designing prodrugs where the benzyl ester and tosylate groups act as protective or promotery functionalities.
• Chemical Biology Probes: Employed in the creation of labeled or tagged molecules for studying neurological pathways and enzyme interactions.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs for client-specific molecule assembly.

Basic Information

Product Name	H-γ-Abu-Obzl p-Tosylate
CAS No.	26727-22-0
Molecular Formula	C19H23NO5S
Molecular Weight	377.46 g/mol
Synonyms	4-Amino-N-(benzyloxycarbonyl)butanoic acid p-toluenesulfonate salt; H-γ-Abu-OBzl p-Tosylate; GABA-OBzl Tosylate; N-Cbz-4-aminobutanoic acid benzyl ester tosylate; γ-Aminobutyric acid benzyl ester N-carboxybenzyl tosylate; (Benzyl 4-((benzyloxy)carbonyl)amino)butanoate 4-methylbenzenesulfonate; Z-4-Abu-OBzl·TosOH
EINECS	Contact for details

Quality Control

Our H-γ-Abu-Obzl p-Tosylate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a Certificate of Analysis (COA) detailing all relevant specifications, available upon request. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and fine chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.