Description

Poly-D-Alanine is a synthetic homopolymer composed exclusively of D-enantiomer alanine amino acid residues. This specific stereochemistry makes it a valuable chiral building block and model compound for advanced biochemical and pharmaceutical research. It is primarily utilized in applications requiring non-natural, protease-resistant peptide structures. Key industries that require this material include pharmaceutical development, peptide synthesis, and academic research into chiral polymers and biomaterials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral component in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biomedical Research: Used as a model substrate for studying enzyme kinetics, protease resistance, and chiral recognition in biological systems.
• Peptide Synthesis: Acts as a building block in solid-phase and solution-phase peptide synthesis to create custom sequences with defined stereochemistry.
• Material Science: Investigated for the development of bio-compatible polymers, hydrogels, and chiral nanomaterials.
• Reference Standard: Employed as a high-purity analytical standard in chromatography (HPLC, UPLC) for method development and quality control.
• Bioconjugation: Utilized in the creation of peptide-drug conjugates or peptide-labeled probes for diagnostic applications.

Basic Information

Product Name	Poly-D-Alanine
CAS No.	26701-36-0
Molecular Formula	(C3H5NO)n
Molecular Weight	n * 71.08 g/mol (monomer unit)
Synonyms	Poly(D-alanine); D-Polyalanine; Poly(D-Ala); (D-Ala)n; Poly-D-alanyl; Poly(alanine) D-form; Poly(D-alanine) homopolymer; D-Alanine homopolymer
EINECS	Contact for details

Quality Control

Our Poly-D-Alanine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with detailed Certificates of Analysis (COA) upon request, which include data for critical parameters such as enantiomeric purity, molecular weight distribution, and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Enantiomeric Purity	≥ 99.0% D-isomer
Molecular Weight (Avg.)	As per customer requirement (e.g., 1k - 10k Da)
Loss on Drying	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.