Description

Polyglutamine CAS NO 26700-71-0 is a synthetic polypeptide composed of repeating glutamine residues, known for its unique structural and biochemical properties. This compound is of significant interest in advanced biomedical and materials research due to its role in protein aggregation studies and as a model for understanding neurodegenerative diseases. It serves as a critical reagent for researchers and developers in the fields of neuroscience, biopharmaceuticals, and polymer science, where precise molecular tools are required.

Application

• Biomedical Research: Used as a model compound to study polyglutamine expansion diseases, such as Huntington's disease and spinocerebellar ataxias.
• Drug Discovery & Screening: Acts as a target or reagent in high-throughput assays to identify potential therapeutic agents that inhibit pathogenic protein aggregation.
• Biomaterial Development: Serves as a building block for creating novel hydrogels, scaffolds, and smart materials with tunable properties for tissue engineering.
• Protein Biochemistry: Utilized in studies of protein folding, misfolding, and amyloid fibril formation mechanisms.
• Diagnostic Tool Development: Employed in the research and development of diagnostic assays and biosensors for neurodegenerative conditions.
• Peptide & Conjugate Synthesis: Functions as a specialized substrate or intermediate for synthesizing more complex peptide conjugates and drug delivery systems.

Basic Information

Product Name	Polyglutamine
CAS No.	26700-71-0
Molecular Formula	(C5H8N2O3)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly-L-glutamine; Poly(Q); PQ; L-Glutamine Homopolymer; Polyglutamine Peptide; Glutamine Homopolymer; Poly(Gln); Huntington's Disease Peptide Model; Poly-L-Gln
EINECS	Contact for details

Quality Control

Our Polyglutamine is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and sequence verification, mass spectrometry for molecular weight distribution, and endotoxin testing where applicable. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and specific purity grades (e.g., >95%, >98%) are available to meet your precise project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption. For extended storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Average Molecular Weight	As specified (e.g., 1kDa, 5kDa, 10kDa)
Moisture Content (KF)	≤ 5.0%
Endotoxin (LAL)	< 10 EU/mg (if specified)
Solubility	Soluble in aqueous buffers, DMSO (limited)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.