Description

H-Leu-Arg-Oh CAS NO 26607-15-8 is a high-purity dipeptide derivative, specifically the C-terminal carboxylic acid form of the leucine-arginine sequence. This compound serves as a critical building block and intermediate in advanced peptide synthesis and pharmaceutical research. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers requiring precise molecular components for drug discovery and biochemical applications.

Application

• Pharmaceutical Intermediate: A key precursor in the solid-phase and solution-phase synthesis of longer therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a standard or substrate in enzymatic studies, particularly those involving proteases or peptidases that recognize the Leu-Arg bond.
• Drug Discovery: Employed in medicinal chemistry programs to develop novel bioactive compounds targeting various physiological pathways.
• Cosmetic Peptide Synthesis: Acts as a raw material for synthesizing peptides used in advanced skincare formulations for anti-aging or moisturizing properties.
• Academic Research: Utilized in university and institutional labs for studying peptide structure, function, and metabolism.

Basic Information

Product Name	H-Leu-Arg-Oh
CAS No.	26607-15-8
Molecular Formula	C12H25N5O4
Molecular Weight	303.36 g/mol
Synonyms	L-Leucyl-L-arginine; Leu-Arg; L-Leu-L-Arg-OH; H-Leu-Arg-OH; Leucine-Arginine dipeptide; 2-[(2-Amino-4-methylpentanoyl)amino]-5-(diaminomethylideneamino)pentanoic acid; (S)-2-((S)-2-Amino-4-methylpentanamido)-5-guanidinopentanoic acid; Arg-Leu (reverse sequence)
EINECS	Contact for details

Quality Control

Our H-Leu-Arg-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation. We provide Certificates of Analysis (COA) with detailed results for all critical parameters, ensuring traceability and compliance with research and cGMP-grade standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.