Description

(D-Ser1)-Acth (1-24) (Human, Bovine, Mouse, Ovine, Porcine, Rabbit, Rat) Trifluoroacetate Salt is a synthetic peptide fragment of adrenocorticotropic hormone (ACTH), modified with a D-serine residue at position 1 to enhance its metabolic stability. This high-purity peptide is critical for research and development in endocrinology, neuroscience, and pharmacology, providing a standardized tool for studying the hypothalamic-pituitary-adrenal (HPA) axis. It is essential for pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers requiring a reliable and well-characterized bioactive peptide for receptor binding studies, bioassay standards, and therapeutic candidate evaluation.

Application

• Biomedical Research: Used as a key reagent in fundamental research on stress response, steroidogenesis, and the physiological functions of ACTH.
• Pharmaceutical Development: Serves as a reference standard and active pharmaceutical ingredient (API) intermediate in the development of diagnostic kits and potential therapeutic agents.
• Bioassay & Potency Testing: Employed as a calibrated standard in in vitro and in vivo bioassays to measure biological activity and ensure batch-to-batch consistency.
• Neuroscience Studies: Facilitates investigation into the role of ACTH fragments in learning, memory, and behavioral models.
• Receptor Binding & Signaling Studies: Utilized in competitive binding assays to characterize melanocortin receptor (MCR) subtypes and study signal transduction pathways.
• Quality Control Reference: Acts as a system suitability standard in analytical methods (e.g., HPLC, MS) for peptide purity and identity confirmation.

Basic Information

Product Name	(D-Ser1)-Acth (1-24) (Human, Bovine, Mouse, Ovine, Porcine, Rabbit, Rat) Trifluoroacetate Salt
CAS No.	26469-81-8
Molecular Formula	C₁₃₆H₂₁₀N₄₀O₃₉S • xC₂HF₃O₂
Molecular Weight	~2933.3 g/mol (free base)
Synonyms	ACTH (1-24), D-Ser-ACTH (1-24); Cosyntropin; Tetracosactide; Synacthen; Cortrosyn; Adrenocorticotropic Hormone Fragment 1-24; [D-Ser¹]-ACTH (1-24); Tetracosactrin; NSC-106568
EINECS	Contact for details

Quality Control

Our (D-Ser1)-Acth (1-24) Trifluoroacetate Salt is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and biological activity, aligning with standards expected for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for HPLC purity, peptide content, amino acid analysis, and mass spectrometry confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 70.0% (by amino acid analysis)
Water Content (KF)	≤ 8.0%
Trifluoroacetate Content	≤ 15.0% (by ion chromatography)
Biological Activity	Assayed by validated in vitro method (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.