Description

H-Ile-Leu-Oh is a high-purity dipeptide building block, specifically the C-terminal carboxylic acid derivative of the isoleucine-leucine sequence. This compound is essential for advanced peptide synthesis, offering researchers and manufacturers precise control over molecular structure and bioactivity. It is primarily utilized in pharmaceutical R&D for developing novel therapeutic peptides, as well as in biochemical studies exploring protein-protein interactions and enzyme substrates.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a standard or substrate in enzymatic studies, metabolic pathway analysis, and proteomics research.
• Cosmeceutical Development: Incorporated into the design of bioactive peptides for anti-aging, moisturizing, or skin-repair cosmetic formulations.
• Nutraceutical Synthesis: Serves as a precursor in creating specialized bioactive peptides for functional food and dietary supplement applications.
• Chemical Biology Tool: Employed in the development of peptide probes, inhibitors, and tags for studying cellular processes and drug discovery.

Basic Information

Product Name	H-Ile-Leu-Oh
CAS No.	26462-22-6
Molecular Formula	C12H24N2O3
Molecular Weight	244.33 g/mol
Synonyms	Isoleucyl-leucine; H-Ile-Leu-OH; Isoleucine-Leucine dipeptide; Ile-Leu; L-Isoleucyl-L-leucine; (2S)-2-[[(2S,3S)-2-Amino-3-methylpentanoyl]amino]-4-methylpentanoic acid; N-(L-Isoleucyl)-L-leucine; 26462-22-6
EINECS	Contact for details

Quality Control

Our H-Ile-Leu-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and residual solvent screening. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	-20° to -25° (c=1 in AcOH)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.