Description

4-Fluoro-L-Glutamic Acid is a fluorinated derivative of the essential amino acid L-glutamic acid, where a fluorine atom is strategically substituted to modulate its biochemical properties. This structural modification makes it a valuable non-natural amino acid building block and a key tool in neuroscience and pharmaceutical research. It is primarily sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors for developing novel compounds and studying neurological pathways.

Application

• Pharmaceutical Intermediate: Used in the research and synthesis of novel drug candidates, particularly those targeting neurological disorders and metabolic diseases.
• Neuroscience Research: Serves as a crucial tool compound for studying glutamate receptors (e.g., as a potential ligand for metabotropic glutamate receptors) and neurotransmission processes.
• Agrochemical Development: Acts as a building block for creating advanced, fluorinated pesticides and herbicides with enhanced activity and selectivity.
• Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships (SAR) and improve metabolic stability or binding affinity.
• Biochemical Probe: Utilized in enzymatic studies to investigate substrate specificity and the mechanism of action of glutamic acid-related enzymes.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4-Fluoro-L-Glutamic Acid
CAS No.	26432-31-5
Molecular Formula	C5H8FNO4
Molecular Weight	165.12 g/mol
Synonyms	(2S)-2-Amino-4-fluoropentanedioic acid; L-4-Fluoroglutamic acid; (S)-2-Amino-4-fluoroglutaric acid; 4-Fluoro-L-glutamate; 4-F-Glu; 4-Fluoroglutamic acid, L-; FA-GLU; 4-Fluoroglutamate
EINECS	Contact for details

Quality Control

Our 4-Fluoro-L-Glutamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.