Description

H-Leu-Leu-Leu-Phe-Ome Hcl is a synthetic tetrapeptide derivative, specifically a protected peptide sequence terminated with a methyl ester and supplied as the hydrochloride salt. This compound serves as a crucial building block and research intermediate in advanced peptide synthesis and pharmaceutical development. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on protease inhibitor design, structure-activity relationship (SAR) studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of complex peptide-based drug candidates and protease inhibitors.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study protease activity and specificity.
• Peptide Chemistry: Serves as a protected fragment for solid-phase or solution-phase peptide synthesis (SPPS) to construct larger, more complex polypeptides.
• Structure-Activity Relationship (SAR) Studies: Employed to investigate the relationship between peptide sequence, structure, and biological function.
• Academic & Contract Research: Utilized in university and CRO laboratories for fundamental research in medicinal chemistry and biochemistry.
• Reference Standard: Can be used as a high-purity analytical standard for quality control and method development in peptide analysis.

Basic Information

Product Name	H-Leu-Leu-Leu-Phe-Ome Hcl
CAS No.	26307-84-6
Molecular Formula	C29H48N4O5 • HCl
Molecular Weight	569.18 g/mol (Free base: 532.72)
Synonyms	Leu-Leu-Leu-Phe-OMe hydrochloride; L-Leucyl-L-leucyl-L-leucyl-L-phenylalanine methyl ester hydrochloride; H-LLLF-OMe•HCl; Tetrapeptide Leu-Leu-Leu-Phe-OMe hydrochloride; N-(N-(N-L-Leucyl-L-leucyl)-L-leucyl)-L-phenylalanine methyl ester hydrochloride; Methyl L-leucyl-L-leucyl-L-leucyl-L-phenylalaninate hydrochloride; LL-3-Phe-OMe HCl
EINECS	Contact for details

Quality Control

Our H-Leu-Leu-Leu-Phe-Ome Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral purity analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be kept under anhydrous conditions. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.