Description

Poly-L-Lysine Hydrochloride is a synthetic, cationic polypeptide derived from the amino acid L-lysine. This compound is valued for its strong positive charge, which makes it an effective cell and tissue adhesive for biological research and a versatile functional polymer in material science. It is essential for researchers and manufacturers in the life sciences, biomedical engineering, and specialty chemical sectors. The product is supplied as a high-purity material suitable for demanding applications.

Application

• Cell Culture & Tissue Engineering: As a coating agent to promote the adhesion and growth of a wide variety of mammalian cells, including difficult-to-attach cell lines.
• Biomedical Research: Used as a non-specific attachment factor for immobilizing proteins, nucleic acids, and other biomolecules on solid surfaces for assays and biosensors.
• Drug Delivery Systems: Serves as a biocompatible cationic polymer for constructing polyelectrolyte multilayers (PEMs) and nano/micro-particle carriers.
• Diagnostic Kits: Employed to pretreat glass slides or other substrates to enhance binding in microarray and immunoassay technologies.
• Material Science: Acts as a functional building block for creating smart hydrogels, antimicrobial surfaces, and conductive polymer composites.
• Food Industry (Research Grade): Studied for its potential as a natural preservative due to its antimicrobial properties against certain bacteria and fungi.

Basic Information

Product Name	Poly-L-Lysine Hydrochloride
CAS No.	26124-78-7
Molecular Formula	(C6H14N2O2•HCl)n
Molecular Weight	(Monomer: 182.65 g/mol) * n
Synonyms	PLL; PLL-HCl; Poly(L-lysine) hydrochloride; L-Lysine homopolymer hydrochloride; Poly(lysine) hydrochloride; ε-Poly-L-lysine hydrochloride; (S)-Poly(amino(4-aminobutyl)acetic acid) hydrochloride; H-(Lys)n-OH•HCl
EINECS	Contact for details

Quality Control

Our Poly-L-Lysine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure high purity, consistent molecular weight distribution, and performance in cell attachment assays. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for assay, endotoxin levels (where applicable), and bioburden. We support compliance with ISO 13485 and cGMP standards for research and biomedical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccants are recommended. Allow the product to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (Nitrogen)	≥ 95.0%
Molecular Weight Range	15,000 - 150,000 Da (other ranges available)
pH (1% solution)	4.0 - 6.0
Loss on Drying	≤ 5.0 %
Endotoxin (if specified)	< 0.1 EU/mg
Bioburden	< 100 CFU/g

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.