Description

Poly-L-Histidine Hydrochloride is a high-purity, synthetic polypeptide derivative of the essential amino acid L-Histidine. This compound is a critical reagent in advanced biochemical research and pharmaceutical development, valued for its unique buffering capacity and metal-chelating properties. It is primarily utilized by researchers and manufacturers in the biopharmaceutical, diagnostic, and life science sectors for applications ranging from drug delivery systems to enzyme immobilization.

Application

• Pharmaceutical Research & Drug Delivery: As a key component in the development of pH-sensitive drug delivery vehicles and polymeric carriers for targeted release.
• Bioconjugation & Immobilization: For the surface modification of nanoparticles and the immobilization of enzymes or antibodies in biosensor and diagnostic assay development.
• Cell Culture & Tissue Engineering: Used in the synthesis of bioactive scaffolds and coatings to promote cell adhesion and growth.
• Biochemical Buffering Agent: Employed in specialized buffer systems where its imidazole group provides effective buffering in the physiological pH range.
• Catalysis & Enzyme Mimics: Serves as a model compound for studying metalloenzyme activity and designing synthetic catalysts.
• Polymer Science: As a monomer or building block for synthesizing functionalized, biodegradable polymers with tailored properties.

Basic Information

Product Name	Poly-L-Histidine Hydrochloride
CAS No.	26062-48-6
Molecular Formula	(C6H9N3O2 • HCl)n
Molecular Weight	Variable (Mw dependent on polymerization degree 'n')
Synonyms	Poly(L-histidine) hydrochloride; Polyhistidine hydrochloride; P(L-His)HCl; L-Histidine homopolymer hydrochloride; Poly(1H-imidazole-4-ethylamine) hydrochloride; Histidine polymer hydrochloride; PLH • HCl
EINECS	Contact for details

Quality Control

Our Poly-L-Histidine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including determination of molecular weight distribution, purity assessment, and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (Ninhydrin)	≥ 95.0%
Molecular Weight (Mw)	As specified (e.g., 1k-20k Da)
Polydispersity Index (PDI)	≤ 1.5
Chloride Content	10.0 - 12.0 %
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.