Description

Boc-D-Met-Osu CAS NO 26060-98-0 is a high-purity, protected amino acid derivative, specifically the N-Boc-protected active ester of D-Methionine. This compound is a critical building block in the synthesis of complex peptides and peptidomimetics, offering excellent control over stereochemistry and reaction pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, chiral catalysts, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the controlled, sequential incorporation of D-Methionine into peptide chains, enabling the creation of non-natural or mirror-image peptides for drug discovery.
• Solution-Phase Peptide Coupling: Used as an activated ester for efficient amide bond formation in solution, particularly valuable for synthesizing short peptide sequences or peptide conjugates.
• Pharmaceutical Intermediate: Serves as a crucial chiral intermediate in the research and development of potential active pharmaceutical ingredients (APIs), especially those targeting metabolic or neurological pathways.
• Bioconjugation and Probe Development: Facilitates the site-specific labeling of proteins, antibodies, or other biomolecules with methionine analogs for diagnostic, imaging, or therapeutic purposes.
• Academic and Industrial Research: Employed in chemical biology and medicinal chemistry research to study enzyme mechanisms, receptor-ligand interactions, and to explore new chemical space for drug candidates.
• Production of Chiral Auxiliaries and Catalysts: The D-configuration makes it valuable for constructing chiral ligands, organocatalysts, or auxiliaries used in asymmetric synthesis.

Basic Information

Product Name	Boc-D-Met-Osu
CAS No.	26060-98-0
Molecular Formula	C15H24N2O6S
Molecular Weight	360.43 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-methionine N-hydroxysuccinimide ester; Boc-D-Methionine N-succinimidyl ester; (R)-2-((tert-Butoxycarbonyl)amino)-4-(methylthio)butanoic acid 2,5-dioxopyrrolidin-1-yl ester; D-Methionine, N-[(1,1-dimethylethoxy)carbonyl]-, 1,2,5-pyrrolidinetrione deriv.; Boc-D-Met-OSu; Boc-D-Met-ONSu; N-Boc-D-Methionine succinimidyl ester; tert-Butyloxycarbonyl-D-methionine N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Boc-D-Met-Osu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile; slightly soluble in dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.