Description

Polysarcosine is a synthetic, non-ionic, and biodegradable poly(amino acid) derived from the amino acid sarcosine (N-methylglycine). This polymer is highly valued for its excellent biocompatibility, water solubility, and stealth properties, making it a critical functional material in advanced biomedical and cosmetic formulations. It is primarily utilized by pharmaceutical developers, bioconjugation specialists, and high-performance cosmetic formulators seeking to enhance product stability and efficacy.

Application

• Drug Delivery Systems: As a hydrophilic, protein-resistant polymer for creating stealth coatings on nanoparticles, liposomes, and micelles to prolong circulation time.
• Bioconjugation & PEGylation Alternative: Serving as a biocompatible linker or spacer for attaching drugs, dyes, or targeting moieties to biomolecules, offering advantages over traditional PEG.
• Protein Stabilization: Used to reduce protein aggregation and improve the shelf-life and stability of therapeutic proteins and peptides.
• Advanced Cosmetics: As a film-forming agent, moisturizer, or carrier for active ingredients in skincare and haircare products due to its non-irritating and hydrating properties.
• Diagnostic Agents: In the formulation of contrast agents for medical imaging (e.g., MRI) to improve biocompatibility and biodistribution.
• Hydrogel Formation: As a component in the synthesis of biocompatible hydrogels for tissue engineering and controlled release applications.

Basic Information

Product Name	Polysarcosine
CAS No.	25951-24-0
Molecular Formula	(C3H5NO)n
Molecular Weight	Variable (based on degree of polymerization, n)
Synonyms	Poly(N-methylglycine); Poly(sarcosine); PSAR; Poly(Sar); Poly(N-methylaminoacetic acid); NSC 334358; Poly(amino acid) from sarcosine
EINECS	Contact for details

Quality Control

Our Polysarcosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analysis to ensure consistent molecular weight distribution, purity, and functional performance. We provide detailed Certificates of Analysis (COA) that include data for key parameters such as degree of polymerization, polydispersity index (PDI), and residual solvent content, supporting applications in GMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent moisture uptake, which can affect material properties.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Average Molecular Weight (Mn)	As per customer grade (e.g., 2kDa, 5kDa, 10kDa, 20kDa)
Polydispersity Index (PDI)	≤ 1.2 (by GPC)
Assay (Purity)	≥ 95% (by NMR)
Residual Solvents	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
End-group Functionality	Controlled (e.g., amine, carboxyl, NHS ester)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.