Description

3-Nitro-4-(Trifluoromethyl)Phenol is a versatile aromatic compound featuring both nitro and trifluoromethyl substituents, which confer unique electronic and steric properties. This combination makes it a valuable high-purity intermediate for the synthesis of more complex molecules in advanced research and manufacturing. It is primarily sought after by the pharmaceutical and agrochemical industries for developing active ingredients, as well as by material scientists for creating specialty polymers and dyes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Dye and Pigment Manufacturing: Serves as a precursor for developing high-performance, light-fast organic dyes and pigments.
• Polymer Science: Acts as a monomer or modifier in the synthesis of specialty polymers, including liquid crystals and high-performance resins.
• Chemical Research: An important reagent in organic synthesis for studying nitration and fluorination reactions, as well as structure-activity relationships (SAR).
• Material Science: Used in the development of advanced materials, such as organic semiconductors and non-linear optical (NLO) materials.

Basic Information

Product Name	3-Nitro-4-(Trifluoromethyl)Phenol
CAS No.	25889-36-5
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	4-Hydroxy-2-nitrobenzotrifluoride; 2-Nitro-α,α,α-trifluoro-p-cresol; 3-Nitro-α,α,α-trifluoro-p-cresol; 4-(Trifluoromethyl)-2-nitrophenol; 2-Nitro-4-(trifluoromethyl)phenol; Phenol, 3-nitro-4-(trifluoromethyl)-; NSC 403107
EINECS	Contact for details

Quality Control

Our 3-Nitro-4-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.