Description

L-Proline, 3-Amino-, (3R)- (9Ci) CAS NO 25876-88-4 is a non-proteinogenic amino acid derivative, specifically a stereoisomerically pure (3R)-configured 3-aminoproline. This compound matters as a sophisticated chiral building block and intermediate, offering precise stereochemical control for the synthesis of complex bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced peptide chemistry, medicinal chemistry, and the development of novel therapeutics and diagnostics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptide-based drugs, enzyme inhibitors, and other bioactive compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the design of novel pharmacophores targeting various diseases.
• Peptide Synthesis: Serves as a modified proline residue to introduce conformational constraints, enhance metabolic stability, or alter the biological activity of synthetic peptides.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies, particularly those involving proline metabolism or proline-specific enzymes.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce enantioselectivity.
• Diagnostic Agent Development: Potential use in the synthesis of labeled compounds for imaging and diagnostic applications.

Basic Information

Product Name	L-Proline, 3-Amino-, (3R)- (9Ci)
CAS No.	25876-88-4
Molecular Formula	C5H10N2O2
Molecular Weight	130.15 g/mol
Synonyms	(3R)-3-Aminoproline; (R)-3-Aminoproline; (3R)-3-Aminopyrrolidine-2-carboxylic Acid; 3-Amino-L-proline; L-3-Aminoproline; 3-Aminoproline; (R)-3-Aminopyrrolidine-2-carboxylic Acid; 25876-88-4
EINECS	Contact for details

Quality Control

Our L-Proline, 3-Amino-, (3R)- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and chiral integrity, meeting the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing specific test results, including chiral purity by HPLC, is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.