Description

2-8-Angiotensin II, 2-Glycine-5-L-Isoleucine- is a specific, biologically active peptide fragment of the angiotensin II hormone. This compound is of significant value in biochemical and pharmaceutical research for studying the renin-angiotensin system (RAS), which regulates blood pressure and fluid balance. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical developers for use as a reference standard, in assay development, and for investigating cardiovascular and renal pathologies.

Application

• Biochemical Research: Used as a critical reference standard and substrate in studies of the renin-angiotensin-aldosterone system (RAAS) and its role in hypertension, heart failure, and kidney disease.
• Diagnostic Assay Development: Serves as a key antigen or calibrator in the development and validation of immunoassays (e.g., ELISA) for measuring angiotensin peptides or related enzymes like ACE.
• Pharmaceutical R&D: Employed in screening and pharmacological studies to evaluate the efficacy of potential drug candidates targeting angiotensin receptors or pathways.
• Enzyme Activity Studies: Acts as a specific substrate for angiotensin-converting enzyme (ACE) to study enzyme kinetics and inhibition.
• Cell Signaling Research: Used to investigate intracellular signaling cascades and receptor binding mechanisms triggered by angiotensin II fragments.

Basic Information

Product Name	2-8-Angiotensin II, 2-Glycine-5-L-Isoleucine-
CAS No.	25849-90-5
Molecular Formula	C41H62N12O10
Molecular Weight	883.02 g/mol
Synonyms	Angiotensin II (2-8); Angiotensin II Fragment 2-8; [Gly1, Ile5]-Angiotensin II (2-8); H-Gly-Arg-Val-Tyr-Ile-His-Pro-OH; Asp-Arg-Val-Tyr-Ile-His-Pro (1-7) substituted with Gly at position 1; DRVYIHP (1-7) with Gly1; Angiotensin (2-8) heptapeptide
EINECS	Contact for details

Quality Control

Our 2-8-Angiotensin II, 2-Glycine-5-L-Isoleucine- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA) providing full specifications and test results is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.