Description

2-Trifluoroacetylphenol is a versatile fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoroacetyl group, which serves as a key building block for introducing fluorinated motifs into target molecules. This compound is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems to improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials for improved thermal and chemical resistance.
• Chemical Research Reagent: Utilized in academic and industrial R&D for exploring new fluorination methodologies and constructing complex molecular architectures.
• Dye and Pigment Intermediate: Acts as a key component in the production of specialized fluorinated dyes and pigments with unique colorfastness and stability properties.

Basic Information

Item	Details
Product Name	2-Trifluoroacetylphenol
CAS No.	25666-51-7
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	1-(2-Hydroxyphenyl)-2,2,2-trifluoroethanone; 2-Hydroxy-α,α,α-trifluoroacetophenone; α,α,α-Trifluoro-2-hydroxyacetophenone; 2-Trifluoroacetylphenol; 2-Hydroxyphenyl trifluoromethyl ketone; o-Trifluoroacetylphenol; 2-(Trifluoroacetyl)phenol
EINECS	Contact for details

Quality Control

Our 2-Trifluoroacetylphenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets stringent specifications for high-purity intermediates. Certificates of Analysis (COA) documenting all test results are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.