Description

4-Fluorotryptophan is a fluorinated derivative of the essential amino acid tryptophan, distinguished by the substitution of a fluorine atom at the 4-position of the indole ring. This structural modification significantly alters its biochemical properties, making it a valuable non-natural amino acid for advanced research and development. It is primarily sought after by researchers and manufacturers in the pharmaceutical and biotechnology sectors for its utility in probing protein structure and function, as well as in the development of novel therapeutic agents and diagnostic tools.

Application

• Biophysical Research: Used as a site-specific infrared and fluorescence probe in protein folding, dynamics, and ligand-binding studies due to its unique spectroscopic signature.
• Pharmaceutical Development: Incorporated into peptide-based drugs and biologics to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Metabolic Pathway Analysis: Serves as a tracer or an analog to study tryptophan metabolism and the biosynthesis of related compounds in biological systems.
• Enzyme Mechanism Studies: Acts as a substrate or inhibitor analog for enzymes involved in tryptophan metabolism, such as tryptophan hydroxylase and indoleamine 2,3-dioxygenase.
• Structural Biology: Utilized in X-ray crystallography and NMR spectroscopy to solve complex protein structures and understand molecular interactions.
• Chemical Biology Tool: Employed in the synthesis of labeled proteins for advanced imaging and diagnostic applications.

Basic Information

Product Name	4-Fluorotryptophan
CAS No.	25631-17-8
Molecular Formula	C₁₁H₁₁FN₂O₂
Molecular Weight	222.22 g/mol
Synonyms	(2S)-2-Amino-3-(4-fluoro-1H-indol-3-yl)propanoic acid; 4-Fluoro-DL-tryptophan; 4-F-DL-Trp; 4-Fluoroindole-3-alanine; DL-4-Fluorotryptophan; 4-FT; 4-Fluorotryptophan, DL-; F4W
EINECS	Contact for details

Quality Control

Our 4-Fluorotryptophan is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical data including HPLC purity, chiral purity (where applicable), and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting compliance with our stringent in-house specifications. Custom synthesis and purification to meet specific research-grade or GMP starting material standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.