Description

Caerulein(4-10), Nle(8)- is a synthetic peptide fragment of the natural hormone caerulein, known for its potent biological activity. This compound is a critical research tool for studying cholecystokinin (CCK) receptors and gastrointestinal physiology. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on metabolic and neurological disorders. The product is supplied to exacting standards to ensure reliable and reproducible experimental results.

Application

• Pharmacological Research: Used as a selective agonist for studying CCK receptor subtypes (CCKA and CCKB) in vitro and in vivo.
• Gastrointestinal Studies: Investigates the regulation of pancreatic secretion, gallbladder contraction, and gut motility.
• Neuroscience Research: Explores the role of CCK in satiety, anxiety, pain perception, and dopamine-mediated behaviors.
• Drug Discovery: Serves as a reference standard and lead compound in the development of novel therapeutics for obesity, pancreatitis, and CNS disorders.
• Biochemical Assay Development: Used in the calibration and validation of receptor binding and functional assays.
• Academic & Institutional Research: Supports basic science investigations into peptide hormone signaling pathways.

Basic Information

Product Name	Caerulein(4-10), Nle(8)-
CAS No.	25613-79-0
Molecular Formula	C41H58N10O11S2
Molecular Weight	939.1 g/mol
Synonyms	Ceruletide (4-10) fragment; Nle8-Caerulein(4-10); Norleucine8-Caerulein(4-10); pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Nle-Met-Asp-Phe-NH2; Caerulein (4-10) heptapeptide; CCK-8 analogue; Cholecystokinin octapeptide fragment; L-Norleucine8-Caerulein(4-10)
EINECS	Contact for details

Quality Control

Our Caerulein(4-10), Nle(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and impurity profiles are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.