Description

Methyl n-(5-Oxo-L-Prolyl)-L-Histidinate is a high-purity synthetic peptide derivative, specifically a methyl ester of a proline-histidine dipeptide. This compound is a critical intermediate in advanced pharmaceutical synthesis and biochemical research, valued for its role in constructing complex peptide structures. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on peptide-based therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or reference standard in enzymatic studies and proteomics research.
• Peptide Synthesis: Essential precursor for solid-phase and solution-phase peptide synthesis (SPPS) to create longer, biologically active peptide chains.
• Diagnostic Reagent Development: Employed in the development of diagnostic assays and biomarkers that target specific peptide sequences.

Basic Information

Product Name	Methyl n-(5-Oxo-L-Prolyl)-L-Histidinate
CAS No.	25575-88-6
Molecular Formula	C13H18N4O4
Molecular Weight	294.31 g/mol
Synonyms	Methyl N-(5-Oxo-L-prolyl)-L-histidinate; L-Histidine, N-[(5-oxo-L-prolyl)]-, methyl ester; Methyl (2S)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoate; Methyl 5-Oxo-L-prolyl-L-histidinate; Pro-His-OMe; 5-Oxo-Pro-His-OMe; Methyl ester of N-(5-Oxo-L-prolyl)-L-histidine
EINECS	Contact for details

Quality Control

Our Methyl n-(5-Oxo-L-Prolyl)-L-Histidinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.