Description

Poly-N(5)-(3-Hydroxypropyl)-1-Glutamine is a synthetic polyamino acid derivative, specifically a modified form of polyglutamine. This engineered polymer is valued for its unique combination of biocompatibility, water solubility, and the presence of reactive hydroxyl groups along its side chain. It serves as a versatile intermediate and functional material for advanced research and industrial applications. Key industries that utilize this specialty polymer include pharmaceutical development, biomedical engineering, and advanced material science.

Application

• Pharmaceutical Excipient & Drug Delivery: Used as a biodegradable carrier or conjugate for controlled-release formulations and targeted drug delivery systems.
• Biomedical Hydrogels & Scaffolds: Serves as a building block for creating biocompatible hydrogels and 3D scaffolds for tissue engineering and regenerative medicine.
• Protein & Peptide Modification: Acts as a polymeric modifier to enhance the stability, solubility, or pharmacokinetic properties of therapeutic peptides and proteins.
• Cosmetic & Personal Care Formulations: Employed as a film-forming agent, moisturizer, or viscosity modifier in high-performance skincare products.
• Bioconjugation & Immobilization Matrix: Provides a functionalized polymer backbone for the covalent immobilization of enzymes, antibodies, or other biomolecules in diagnostic assays and biosensors.
• Specialty Coatings & Adhesives: Used in the development of bio-based, non-toxic coatings and adhesives for medical devices.

Basic Information

Item	Detail
Product Name	Poly-N(5)-(3-Hydroxypropyl)-1-Glutamine
CAS No.	25569-41-9
Molecular Formula	(C8H14N2O4)n
Molecular Weight	~202.21 (monomer unit)
Synonyms	Poly(3-Hydroxypropyl-L-glutamine); PHPLG; Poly(Hydroxypropylglutamine); Poly-N5-(3-Hydroxypropyl)-L-glutamine; Hydroxypropyl Polyglutamate; HP-PGA; P(HPG); L-Glutamine, N5-(3-hydroxypropyl)-, homopolymer
EINECS	Contact for details

Quality Control

Every batch of Poly-N(5)-(3-Hydroxypropyl)-1-Glutamine is manufactured under a strict quality management system. Our products undergo rigorous analytical testing to ensure consistent purity, molecular weight distribution, and functional group integrity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing key parameters such as assay, degree of substitution, and residual solvent content. We adhere to cGMP principles for production relevant to pharmaceutical-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect physical properties. For long-term storage (>12 months), consider storage under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (NMR/Titration)	≥ 95.0%
Degree of Substitution	As per customer requirement
Weight-Average Molecular Weight (Mw)	Specified range (e.g., 5kDa - 50kDa)
Polydispersity Index (PDI)	≤ 2.0
Loss on Drying	≤ 5.0 %
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.