Description

3-Amino-4-Methylbenzotrifluoride is a versatile trifluoromethylated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, combining an amino group with a trifluoromethyl substituent on a methylbenzene core, makes it a high-value intermediate for introducing fluorine-containing motifs, which are prized for their ability to modulate the physicochemical properties of target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials with enhanced metabolic stability, lipophilicity, and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology, where the trifluoromethyl group improves drug-like properties.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to increased biological activity, environmental stability, and selective action.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing aromatic diamines and other monomers used in the production of high-performance electronic display materials and organic light-emitting diodes (OLEDs).
• Dye & Pigment Manufacturing: Serves as an intermediate for synthesizing specialized, light-fast dyes and pigments, leveraging the amino group for coupling reactions.
• Polymer Modification: Incorporated into polymer chains as a functional monomer to create fluorinated polymers with unique surface characteristics, chemical resistance, and thermal stability.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel fluorinated compounds for various applications.

Basic Information

Product Name	3-Amino-4-Methylbenzotrifluoride
CAS No.	25499-96-1
Molecular Formula	C8H8F3N
Molecular Weight	175.15 g/mol
Synonyms	4-Methyl-3-(trifluoromethyl)aniline; 3-Amino-4-methyl-α,α,α-trifluorotoluene; 3-Amino-4-methylbenzotrifluoride; 3-Trifluoromethyl-4-methylaniline; 4-Methyl-3-trifluoromethylaniline; 3-Amino-4-methyl-1-(trifluoromethyl)benzene; 2-Amino-5-methylbenzotrifluoride (alternate numbering); 3-Amino-4-methyl-α,α,α-trifluoromethylbenzene
EINECS	Contact for details

Quality Control

Our 3-Amino-4-Methylbenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring reliability for critical applications in pharmaceutical and agrochemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen) for long-term preservation. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.